Establishment of Wolbachia Strain wAlbB in Malaysian Populations of Aedes aegypti for Dengue Control

WA Nazni; AA Hoffmann; A NoorAfizah; YL Cheong; MV Mancini; N Golding; GMR Kamarul; MAK Arif; H Thohir; H NurSyamimi; MZ ZatilAqmar; M NurRuqqayah; A NorSyazwani; A Faiz; FRMN Irfan; S Rubaaini; N Nuradila; NMN Nizam; SM Irwan; NM Endersby-Harshman; VL White; TH Ant; CS Herd; AH Hasnor; R AbuBakar; DM Hapsah; K Khadijah; D Kamilan; SC Lee; YM Paid; K Fadzilah; O Topek; BS Gill; HL Lee; SP Sinkins

Journal article

Establishment of Wolbachia Strain wAlbB in Malaysian Populations of Aedes aegypti for Dengue Control

WA Nazni, AA Hoffmann, A NoorAfizah, YL Cheong, MV Mancini, N Golding, GMR Kamarul, MAK Arif, H Thohir, H NurSyamimi, MZ ZatilAqmar, M NurRuqqayah, A NorSyazwani, A Faiz, FRMN Irfan, S Rubaaini, N Nuradila, NMN Nizam, SM Irwan, NM Endersby-Harshman Show all

Current Biology | Published : 2019

DOI: 10.1016/j.cub.2019.11.007

Open access

Download PDF

Abstract

Nazni et al. show that the wAlbB Wolbachia infection can successfully invade Malaysian field populations of Aedes aegypti mosquitoes, which are responsible for dengue transmission. There was a decrease in dengue incidence at the release sites, highlighting the potential of this strategy to suppress dengue in hot tropical environments.

University of Melbourne Researchers

Ary Hoffmann Author

Nicholas Golding Author

Nancy Endersby Author

Related Projects (2)

ENHANCING DISEASE VECTOR BIOSECURITY THROUGH HIGH DENSITY MOLECULAR MARKERS

The outbreak of several diseases spread by mosquitoes is increasing rapidly around the world, driven by increased people movement spreading ..

WOLBACHIA FOR BIOCONTROL OF EMERGENT ARBOVIRUSES

Dengue, Zika and Chikungunya are viral diseases transmitted to humans by mosquitoes. Our research uses a naturally-occurring bacteria, Wolba..

Grants

Awarded by Kementerian Kesihatan Malaysia

Funding Acknowledgements

The primary funding for the study was provided by Wellcome Trust Award 108508, with additional funding from Wellcome Trust Award 202888 and National Health and Medical Research Council of Australia Awards 1118640 and 1132412 and funding from Ministry of Health Malaysia. The authors thank the Director General of Health, Malaysia, for permission to publish. Thanks are also due to the Deputy Director General of Health (Research & Technical Support), Malaysia, and Director, Institute for Medical Research, Kuala Lumpur, for the support. We acknowledge Datuk Dr. Shahnaz Murad and Dr. Rose Nani Mudin for the support throughout the project.